Gall-bladder visualization by the oral route depends on an adequate blood level of dye following its absorption, its removal and excretion by the liver, and its entrance into and concentration by the gall bladder. It has been frequently stated that cholecystography is contraindicated in liver disease with jaundice, for one cannot determine whether the failure of visualization is due to liver or to gall-bladder disease. This study, which correlates the serum bilirubin level, the retention of sulfobromophthalein (Bromsulphalein) dye, and gall-bladder visualization in 40 patients with varying degrees of liver disease is an attempt to clarify the problem.
Forty patients with varying degrees of impaired liver function were selected for study. Tests of liver function and oral cholecystography were performed the same morning. Six tablets of iopanoic acid U. S. P. (Telepaque) were given the preceding evening. The sulfobromophthalein method consisted of the intravenous administration of 5 mg. of
MANDEL W, GAINES LM, MARILLEY RJ. Evaluation of Oral Cholecystography in Liver Disease. AMA Arch Intern Med. 1956;97(3):335-339. doi:10.1001/archinte.1956.00250210081007