Recently, in an experiment designed to study the effects of the intraoral application of tobacco tar as a carcinogenic agent in mice, Holsti and Ermala observed that about 75% of the mice developed urinary bladder papillomas in contrast to none of the control group and that 10% of the experimental group had papillomas that were histologically malignant.1 It would be of considerable interest to determine if in humans a similar relationship exists. As a first approach to the study of such a relationship, the clinical records of patients admitted to the Roswell Park Memorial Institute were reviewed. This is a report of the results of this analysis.
Method of Study
The method of study consisted of a comparison of the histories of tobacco use of a group of patients with urinary bladder cancer with those of patients with other cancers and noncancerous conditions. The other cancers selected for study
LILIENFELD AM, LEVIN ML, MOORE GE. The Association of Smoking with Cancer of the Urinary Bladder in Humans. AMA Arch Intern Med. 1956;98(2):129–135. doi:10.1001/archinte.1956.00250260001001