January 1957

An Intrafamilial Epidemic of Pharyngoconjunctival Fever

Author Affiliations

Columbus, Ohio

From the Department of Medicine, Ohio State University College of Medicine and The Ohio State Health Department Laboratories.

AMA Arch Intern Med. 1957;99(1):70-73. doi:10.1001/archinte.1957.00260010072010

Pharyngoconjunctival fever has become recently recognized as a specific viral disease entity characterized by fever, pharyngitis, and conjunctivitis occurring singly or in combination, in epidemic or sporadic form.1-3 Virus-isolation studies and the subsequent development and application of APC group-specific complement-fixation and type-specific neutralization tests have shown that APC Type 3 virus is the etiologic agent.1-4 Epidemics have been reported from widely separated areas.2-5 Since this disease entity may be confused with a variety of other infections or may be mild enough not to require the services of a physician, many cases are probably not recognized or reported. It is the purpose of this study to describe the disease as it appeared in a family of seven.

Report of Cases 

Case 1.  —A 12-year-old white boy was admitted to the Ohio State University Hospital on July 16, 1955, because of a six-day illness, characterized by pharyngitis, unilateral conjunctivitis,

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