While it is still a rare disease, over 200 cases of human cryptococcosis have been reported in the literature. The vast majority of these cases show involvement of the central nervous system. The lungs are believed to be the next most frequently diseased site. In fact, the respiratory tract is considered by many 5,6,8 to be the portal of entry of Cryptococcus neoformans. In spite of this, the literature available to us contained reports of fewer than 25 cases of pulmonary cryptococcosis without associated central nervous system or other involvement.
Berk and Gerstl 4 reviewed the literature in 1952 and found five cases of primary pulmonary cryptococcosis; they also reported one case of their own treated by lobectomy. Baker 1 reported three cases of primary pulmonary involvement which were successfully resected. Linden and Steffen 7 reported an interesting case of cryptococcal pneumonitis that developed in a patient receiving corticotropin and
CORNISH AL, BALOWS A, CHIPPS HD, HOLLOWAY JB. Isolated Pulmonary Cryptococcosis. AMA Arch Intern Med. 1957;99(2):285-289. doi:10.1001/archinte.1957.00260020121017