July 1957

Influence of Promazine and Methylphenidate on Cerebral Hemodynamics and Metabolism

Author Affiliations

Washington, D. C.

From the George Washington and Georgetown University Medical Divisions, District of Columbia General Hospital.

AMA Arch Intern Med. 1957;100(1):66-69. doi:10.1001/archinte.1957.00260070080008

Promazine, a new phenothiazine derivative, appears to offer considerable promise in the control of patients with increased psychomotor activity 1,2 as well as assisting in the management of patients with various medical emergencies.3 The exact physiological mechanism by which this drug exerts its effects is not known; however, previous studies4 have shown chlorpromazine, a somewhat similar phenothiazine derivative, to have no demonstrable effects upon total cerebral hemodynamics and oxygen utilization. It was nevertheless considered worth while to determine whether this was also true of promazine. In addition, this study afforded the opportunity to examine the clinical and quantitative cerebral effects of methylphenidate hydrochloride (an analeptic drug) alone and upon subjects to whom promazine had been previously administered.

Methods  The subjects of the present study were 21 hospital patients who had been admitted for a variety of acute illnesses but were convalescent and otherwise in reasonably good condition. They

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