August 1957

Agammaglobulinemia Associated with Pernicious Anemia and Diabetes Mellitus

Author Affiliations

Coral Gables, Fla.

From the Surgical Service (Dr. Lewis) and Medical Service (Dr. Brown), Veterans' Administration Hospital.

AMA Arch Intern Med. 1957;100(2):296-299. doi:10.1001/archinte.1957.00260080122024

Agammaglobulinemia, or hypogammaglobulinemia, as it is now being referred to by some authors, was first described as a clinical entity in 1952.1 Since that time there have been a number of excellent papers on this subject,2-4 but the total number of reported cases is still relatively small. It is not the purpose of this paper to review this subject of agammaglobulinemia, but rather to present a case in which agammaglobulinemia, pernicious anemia, and diabetes mellitus are present.

Abnormalities of the hemopoietic system are not infrequently seen associated with agammaglobulinemia,4-6 but this appears to be the first case associated with pernicious anemia. There appears to be one previously reported case associated with diabetes mellitus.7

Agammaglobulinemia is a disease in which γ-globulin is absent or diminished in the serum, with the result that the person so afflicted has little or no resistance to diseases normally combated by immune

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