February 1958

Primary Reticulum-Cell Sarcoma of the Leptomeninges

Author Affiliations


From the Neurological Unit and the Mallory Institute of Pathology, Boston City Hospital. Professor of Neurology, Boston University School of Medicine, and Visiting Physician for Neurology, Boston City Hospital (Dr. Kane); Assistant Professor of Neurology, Harvard Medical School, and Visiting Physician for Neurology, Boston City Hospital (Dr. Foley).

AMA Arch Intern Med. 1958;101(2):333-338. doi:10.1001/archinte.1958.00260140165025

Earlier authors frequently described any rapidly growing, highly cellular intracranial tumor as a "sarcoma." Inadequate clinical and microscopic descriptions, doubtful photomicrographs, the failure to make proper use of special stains, incomplete postmortem examinations, and, especially, the use of multiple synonyms for the same type of tumor makes it very difficult to review the pertinent literature on this subject. More recent discussions are in agreement on one point, however, which is that if one restricts the use of the term "sarcoma" to malignant mesodermal tumors they are very uncommon indeed intracranially. Thus, they made up only 0.7% of 2023 brain tumors in Cushing's1 series and less than 1% of Olivecrona's 2 even larger series of 4188 cerebral neoplasms.

True cerebral sarcomas occur usually as focal tumor masses (isolated or multiple) with or without local involvement of the overlying meninges. They may also begin in the periadventitial tissue of the lepto

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