March 1958

Thyroxin and Triiodothyronine in Excessive Dosage to Euthyroid Humans

Author Affiliations

Ann Arbor, Mich.

From the Department of Internal Medicine and the Mental Health Research Institute, Department of Psychiatry.

AMA Arch Intern Med. 1958;101(3):569-576. doi:10.1001/archinte.1958.00260150057007

The comparative effects of 3,5,3'-l-triiodothyronine and l-thyroxin in myxedema have been carefully evaluated.1 These medications have also been given in physiologic dosage to euthyroid humans to evaluate the effect on the thyroid I131 uptake and serum protein-bound iodine (PBI).2 We have found no information on the comparative effects of "thyrotoxic" dosage of these drugs and the subsequent effect of stopping these medications.

In the course of an evaluation of the effects of induced thyrotoxicosis on mental function,3 interesting new data were accumulated on this aspect of thyroid hormone effect.


Subjects.  —Eighteen healthy male college students ranging in age from 20 to 30 years—average age, 23 years—were screened by medical history, physical examination, 24-hour I131-uptake test, basal metabolic rate (BMR), serum PBI,4 and serum cholesterol5 determination to rule out any question of thyroid disease and to make certain that they could withstand the effects of administration of excessive amounts of

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