July 1958

Primary Aldosteronism with Diabetes Mellitus

Author Affiliations


AMA Arch Intern Med. 1958;102(1):131-133. doi:10.1001/archinte.1958.00260190133015

Although the syndrome of primary aldosteronism is now a recognized entity, the occurrence of diabetes in this disease has not been emphasized until recently.1,2 The clinical picture of periodic muscular weakness, intermittent tetany and paresthesias, polyuria, polydipsia, and hypertension, along with the findings of hypokalemia, hypernatremia, and alkalosis and the demonstration of an aldosterone-secreting tumor of the adrenal, was first described by Conn,3 in 1955. Since then at least 30 cases have been recognized.4 Many have been reported in retrospect from autopsy material. McCullagh 1 and Hewlett et al.2 have recently reported three cases of primary aldosteronism in which a diabetic tendency was a prominent feature. It was felt that the diabetes arises as a result of excess aldosterone secretion and is of a very mild variety.1 It is the purpose of this report to document a case having the clinical and laboratory findings compatible

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