November 1958

The Isolation of Adenovirus Type 1 from a Fatal Case of Viral "Pneumonitis"

Author Affiliations


From the Division of Virology, the Department of Public Health and Preventive Medicine, the University of Pennsylvania School of Medicine, and the Children's Hospital of Philadelphia; the Bryn Mawr Hospital, Bryn Mawr, Pa.

AMA Arch Intern Med. 1958;102(5):816-819. doi:10.1001/archinte.1958.00260220132015

The etiology of acute respiratory infections of childhood and infancy often remains obscure. Progress has been made, however, in the classification of these illnesses by the recent discovery of a new group of viruses, subdivided into distinct serotypes, which are now referred to as adenoviruses,1 formerly the APC,2 RI,3 or ARD4 groups. Adenoviruses have been shown to be a cause of undifferentiated acute respiratory disease, nonstreptococcal exudative pharyngitis, and primary atypical pneumonia. They were also found to be associated with a clinical entity designated pharyngoconjunctival fever, which may assume epidemic proportions.3-8 Other illnesses have been ascribed to these agents which include epidemic keratoconjunctivitis9,10 and mesenteric lymphadenitis,11 and a Type 3 of these agents has been isolated from a stool of an infant with a disease resembling roseola infantum.12 While in general the diseases induced appear to be relatively mild, adenoviruses have been isolated from the lungs of two fatal cases

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