[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.166.48.3. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
January 1959

Thrombotic Thrombocytopenic PurpuraTwo Patients with Remission Associated with the Use of Large Amounts of Steroids

Author Affiliations

Nashville, Tenn.

From the Department of Medicine, Vanderbilt University School of Medicine and Hospital.

AMA Arch Intern Med. 1959;103(1):105-112. doi:10.1001/archinte.1959.00270010111014
Abstract

In 1954, Singer reviewed the subject of thrombotic thrombocytopenic purpura, collecting 55 cases from the literature.1 Wile and Sturgeon, in 1956, compiled an additional 19 instances and added 3 case reports in children.2 We are aware of an additional 25 reports during the years 1954-1957, bringing the total number of cases to over 100 3-27 In general the clinical course of this disorder has been most unfavorable, the majority of patients dying within eight weeks of the recognized onset of the disease. In rare instances survival for more than one year has been reported.23,24,26,28,29 Several of these patients had atypical manifestations, so that it is difficult to ascertain the time of onset of the disease and the survival time in all of these cases.

No well-documented typical case has undergone long-term spontaneous remission, and a variety of therapeutic endeavors has in general failed to influence the course

First Page Preview View Large
First page PDF preview
First page PDF preview
×