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June 1959

Eosinophilic Granuloma of LungClinical Features and Connective Tissue Patterns

Author Affiliations

Jacksonville, Fla.

From the Research Laboratory, Baptist Memorial Hospital, and the Departments of Medicine, Duval Medical Center and St. Vincent's Hospital.

AMA Arch Intern Med. 1959;103(6):966-973. doi:10.1001/archinte.1959.00270060118016

Eosinophilic granuloma may be defined briefly as a chronic inflammatory disorder of unknown etiology characterized primarily by the presence of histiocytes and eosinophils. General awareness of this disease may be said to be a consequence of two almost simultaneous but independent studies which appeared in 1940,1,2 although Mazzitello3 mentions the existence of less well-appreciated earlier descriptions. After 1940 a series of papers appeared in considerable number, and a clinical and pathological spectrum has gradually evolved.

Histologically, many of the cases have shown apparent transitions with two other disorders, namely, the Hand-Schüller-Christian syndrome and Letterer-Siwe disease. So consistent have these similarities been that it is now generally conceded that all three diseases represent variants or interrelated expressions of the same fundamental malady. The over-all group has been designated as "Histiocytosis X" by Lichtenstein,4 histiocytosis referring to the common cell type or histological hallmark and X indicating the need

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