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Article
July 1959

CryptococcosisFurther Observations and Experiences with Amphotericin B

Author Affiliations

Rochester, Minn.

Section of Medicine (Drs. Martin and Nichols), Section of Neurologic Surgery (Dr. Svien), and Section of Bacteriology (Dr. Ulrich), Mayo Clinic and Mayo Foundation. The Mayo Foundation, Rochester, Minn., is a part of the Graduate School of the University of Minnesota.

AMA Arch Intern Med. 1959;104(1):4-14. doi:10.1001/archinte.1959.00270070006002
Abstract

Infections due to Cryptococcus neoformans (Torula histolytica) continue to create diagnostic and therapeutic problems. Since our previously reported experience with this type of infection,1 we have studied eight additional patients with cryptococcosis. Five of these patients have had meningoencephalitis and have been treated with the antibiotic, amphotericin B. Detailed reports of the diagnostic difficulties encountered in these five patients and their response to therapy with amphotericin B seem indicated.

Report of Cases 

Case 1.  —A 43-year-old industrialist first came to the Mayo Clinic in July, 1955, complaining of episodic semiconsciousness and occipital headache of seven months' duration. In April, 1955, he had been hospitalized elsewhere, and culture of his spinal fluid had yielded C. neoformans.Physical findings at the clinic were within normal limits except for marked obesity. Laboratory data on this and subsequent visits included results of urinalyses and estimations of the concentration of hemoglobin, the number of

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