In 1911, F. B. Mallory1 called attention to a peculiar hyaline change in the liver cells in alcoholic cirrhosis. It consisted of the appearance of a coarse, eosinophilic meshwork in the cytoplasm of single hepatic cells or groups of cells, followed by necrosis and invasion by polymorphonuclear leukocytes and mononuclear phagocytes, then by connective tissue proliferation at the site of necrosis. This hyaline change in the liver cells was thought to be so characteristic of the pathogenesis of the cirrhotic process that it was termed "alcoholic hyaline." Subsequently these cytoplasmic changes have been termed "Mallory bodies."
While it has been well established that Mallory bodies are neither limited to the cirrhotic livers of alcoholics nor are peculiar to portal cirrhosis,2,3 they are most frequently seen in portal cirrhosis and most often in the active phase of the disease where inflammatory changes predominate. Thus the presence of Mallory bodies,
RICE JD, YESNER R. The Prognostic Significance of So-Called Mallory Bodies in Portal Cirrhosis. AMA Arch Intern Med. 1960;105(1):99-104. doi:10.1001/archinte.1960.00270130115014