January 1960

Coronary Heart Disease.

Author Affiliations

By John William Gofman, M.D., Ph.D. Price, $8. Pp. xx+, 353, with no illustrations. Charles C Thomas, Publisher 301-327 E. Lawrence Ave., Springfield, Ill.; Ryerson Press, 299 Queen St. W. Toronto; Black-well Scientific Publciations, 24-25 Broad St., Oxford, England, 1959.

AMA Arch Intern Med. 1960;105(1):171-172. doi:10.1001/archinte.1960.00270130187025

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The background of this book is not stated, although it is relevant to its review. Some 10 years ago the author achieved quantitative, differential separation of low-density serum lipoproteins by adjusting the medium to density 1.06 and photographically recording flotation rates during ultracentrifugation. This brilliant technical development was followed by enthusiastic reports that showed a close association between high concentrations of lipoprotein class Sf 12-20 and previous myocardial infarction. Subsequent data extended the correlation to lipoproteins Sf 20-400. The data were numerically expressed by weighing factors as an 'Atherogenic Index,' based on lipoprotein distribution and diastolic pressure. As the author Indicates, this term implies a causal association which is not fully established and which is not essential to this presentation, although he adduces evidence to suggest that it may be valid. His concepts are developed calmly, clearly, and persuasively, with only faint gleams of the contentiousness and

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