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Here is an example of the confusion or corruption of physicians who beat the drum in a symposium on treating "stress" with hesperidin. This throw-away item appeared under the aegis of the Wayne County Chapter of The Michigan Academy of General Practice. Much scientific work has indicated that hesperidin is a not inexpensive placebo. Controlled studies reported by Shils and Goodhart indicated that such flavonoids are without therapeutic effect. It is not surprising that they have been used to treat hypothetical states or diseases for which there is no known cure and others for which better methods of therapy are known. Perhaps the best that can be said for the papers is that they represent the testimonial approach—statements unsupported by evidence. The papers reveal ignorance of disease and of the experimental method. The Michigan Academy of General Practice has done itself and medicine conspicuous disservice in supporting the hard sell
Bean WB. Symposium on Stress and Circulation,. AMA Arch Intern Med. 1960;105(3):498. doi:10.1001/archinte.1960.00270150152020