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May 1960

A Study of Experimental Staphylococcal Endocarditis in DogsII. Penicillin-Sensitive Mutants Arising from Penicillin-Resistant Staphylococcus Aureus During the Course of Experimental Canine Endocarditis

Author Affiliations


From the Infectious Disease Laboratory, Department of Medicine, University of Cincinnati College of Medicine, and the Cincinnati General Hospital.

AMA Arch Intern Med. 1960;105(5):668-674. doi:10.1001/archinte.1960.00270170006002

Introduction  Although an enormous amount of research has been devoted to the problem of drug-resistant microbes developing from drug-sensitive strains, very little attention has been paid to changes in the opposite direction, namely the appearance of sensitive mutants arising from initially resistant microorganisms. That such a change may occur in vivo was suggested by the later disappearance of the widely prevalent sulfonamide-resistant Group A streptococci which had appeared on the scene to frustrate the initial success of the Navy's and Air Force's sulfonamide prophylaxis program during World War II.2 In 1950 Hamburger and Berman3 reported the replacement of streptomycinresistant Escherichia coli which had appeared in the stools of certain tuberculous patients treated with streptomycin by streptomycinsensitive E. coli after cessation of treatment and, on occasion, even during the continuation of treatment. The disappearance of novobiocin-resistant staphylococci from the noses of patients and personnel in the Chicago Municipal Contagious

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