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August 1960

Cystic Fibrosis of the PancreasClinical Features in Adolescence and Early Adult Life

Author Affiliations

Easton, Md.; Baltimore

From the School of Medicine, The Johns Hopkins University, and the Private Medical Service, The Johns Hopkins Hospital.

Arch Intern Med. 1960;106(2):253-260. doi:10.1001/archinte.1960.03820020093014

Cystic fibrosis of the pancreas is primarily a disease of infancy and childhood. Survival into adolescence has been considered a rare occurrence.1 In recent years, however, reports of long-term survival have appeared.2-5 The present study represents an analysis of the clinical features of six adolescent and adult cases.

Case Material  In the records of The Johns Hopkins Hospital and the Harriet Lane Home for Invalid Children, a total of 67 patients with cystic fibrosis of the pancreas were listed. Six of these patients are known to have survived beyond the age of 12 years. These patients are the subject of this report. Clinical criteria for the diagnosis of cystic fibrosis included in each case absence of tryptic activity in the duodenal fluid and/or an elevated sweat chloride concentration.

Case 1.  —A 21-year-old college student was referred to The Johns Hopkins Hospital for evaluation of recurrent upper respiratory infections.

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