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This is a short monograph describing the author's choice of micromethods requiring 0.1 ml. (occasionally 0.2 ml.) of serum or plasma for use in a three-hundred-bed hospital. The methods presented are robust, i.e., are not susceptible to the small variations introduced unconsciously by the technician, must give accurate results consistently when large numbers of analyses must be done quickly, and can be transplanted from one laboratory to another with a minimum of preparation for routine use.
A clear, concise discussion of the techniques of specimen drawing, preservation of samples, pipetting and instrumentation involved in micromethodology is presented.
Prior to the presentation of the specific methods for the various constituents, the author briefly discusses the significance of closely related constituents and the various methods for their determination.
In conclusion, this monograph represents a very practical manual for routine laboratories interested in micromethods.
Routh J. Chemical Micromethods in Clinical Medicine.. Arch Intern Med. 1960;106(3):461. doi:10.1001/archinte.1960.03820030149029