Elevated serum potassium levels unassociated with manifestations of hyperkalemia have been observed in patients with thrombocythemia associated with the myeloproliferative disorder.1-3 Studies indicate that potassium released from platelets during the process of blood coagulation is responsible, since serum prepared from platelet-free plasma has a normal potassium concentration. "Spurious hyperkalemia" has been suggested as a term for this syndrome.3 We wish to reemphasize these findings with additional observations.
Results and Comment
Table 1 lists the clinical and laboratory data in a group of patients with elevations of leukocytes, erythrocytes, and platelets alone or in various combinations. Significant elevations of serum potassium levels above the normal level of 5 mEq. per liter were noted in Patients 1, 4, 5, 6, 7, 8, 9, and 14. In each of these patients there was a significant elevation of the platelet count. In the absence of thrombocythemia, elevations of the leukocyte or erythrocyte
MYERSON RM, FRUMIN AM. Hyperkalemia Associated with the Myeloproliferative Disorder. Arch Intern Med. 1960;106(4):479-482. doi:10.1001/archinte.1960.03820040017003