The association of multiple cutaneous angiomata and limb hypertrophy as a distinct clinical entity, rather than a coincidental combination of two unrelated anomalies, was first described by Trelat and Monad in 1896. Klippel and Trenaunay subsequently described this rare syndrome as "nevus variqueux osteohypertrophique"; and in a series of papers beginning in 1918, Parkes Weber 1-5 discussed the problem of hemangiectatic hypertrophy of limbs. Since that time a few other case reports of this syndrome have been reported.6-9 However, the apparent rarity of this disorder and the interesting speculative relationship with several other obscure entities, including Maffucci's syndrome, have prompted this report.
Report of a Case
A 16-year-old white youth was admitted for treatment of a chronic leg ulcer which had its origin six months previously following an episode of minor trauma to the right lower leg. The patient gave a history of previous poor healing of wounds incurred
BREST AN, PEARCE AE, LIKOFF W. Hemangiomatous Hemihypertrophy of Bone. Arch Intern Med. 1960;106(6):859-861. doi:10.1001/archinte.1960.03820060111012