December 1960

The Treatment of Hyperthyroidism

Arch Intern Med. 1960;106(6):878-888. doi:10.1001/archinte.1960.03820060130016

Numerous developments in thyroidology during the past 15 years have led to an entirely new approach to the treatment of diseases of the thyroid—especially hyperthyroidism. Little has emerged on the cause of toxic goiter, but advances have come in discoveries on the mode of synthesis of thyroid hormone, of certain drugs which block this synthesis, of the action of iodine, and of new agents which lessen the peripheral effects of excess hormone. Of clinical importance are the improved techniques of anesthesia and surgery, the recognition and treatment of toxic reactions to the antithyroid drugs, and the remarkable effectiveness of radioactive iodine in destroying thyroid tissue: thus, therapy has become for the most part highly successful, and it is now necessary for the physician only to select the best form of treatment for each patient. The purpose of this presentation is to point out the advantages and disadvantages of 3 major

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