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A milestone of some sort is reached in a book-reviewing operation when second or subsequent editions come round for attention. This has happened for the first time now in my reviewing Victor McKusick's elegant and searching Heritable Disorders of Connective Tissue. We live in a medical age when genetics is becoming more and more important and when some of the biochemistry and biophysics of the very thread of life, the spiral helix of the nuclear material itself, is being unwound if not unstrung for our edification. Just as what once began as simple rheumatology now includes physical chemistry and immunochemistry as part of its essential material, so enzymic aberrations, structural faults, and other inborn errors are becoming understood as we learn better how genetic messages are carried in chromosomes to build, direct, and monitor the enzymatic templates by which cells not only do their several diverse missions but hew to
Bean WB. Heritable Disorders of Connective Tissue.. Arch Intern Med. 1960;106(6):900. doi:10.1001/archinte.1960.03820060152025