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July 1961

New Diuretics and Antihypertensive Agents

Arch Intern Med. 1961;108(1):164. doi:10.1001/archinte.1961.03620070166022

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The drugs covered in this volume are restricted to those which have appeared within the past four years: the benzothiadiazine, phthalimidine, and spirolactone diuretics, and the antihypertensive agents guanethidine, bretylium, and inhibitors of mononamine oxidase and dopa-decarboxylation.

The specific investigations reported are introduced by six review articles to provide appropriate context. Thus Grollman summarizes the most widely held views of the mechanisms of urine formation and diuretic action; Kirkendall reviews concepts of the mechanisms involved in hypertension, and Imbriglia reviews the pathology of hypertension. In addition, Rennick presents a lucid account of the pharmacodynamics of the new diuretics, based largely on animal studies. Parallel articles for the antihypertensive drugs are presented by Sjoerdsma on monoamine oxidase inhibitors and α-methyl dopa and by Brodie and Kuntzman on agents selectively depleting catechol amines.

Most of the information contained in this volume has been replicated in numerous publications. Bound together as a series

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