August 1961

Effects of Major Surgery on Plasmin-Plasminogen Inhibitors

Author Affiliations


From the Division of Cardiology, Philadelphia General Hospital.

Arch Intern Med. 1961;108(2):208-217. doi:10.1001/archinte.1961.03620080040004

Although alterations in factors influencing blood coagulation have been extensively studied in various disease states,1,2 much less is known about fibrinolysis, the processes by which fibrin deposits and blood clots are dissolved in the living organism.3 Evidence is accumulating that the latter is one of the fundamental processes in physiology.3,4 In recent years highly purified proteolytic and fibrinolytic enzymes have been used by clinicians in the therapeutic management of thromboembolic disorders.5-8 New and more powerful techniques have also become available to study various phases of clot dissolution.9-16 These developments have stimulated a growing interest in the fibrinolytic processes and their modifications by disease.

Increased fibrinolytic activity has been reported in various pathologic states: conditions of stress, such as acute febrile infections,17 electroshock and anoxia,18 obstetrical complications, such as premature separation of the placenta,19 after pulmonary surgery,4 and after extensive carcinoma of

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