Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
February 1962

Carcinoid Syndrome Associated with Adrenal Hyperplasia

Author Affiliations


From the Department of Medicine, University of Minnesota Medical School and University Hospitals: Instructor (Dr. Davis); Associate Professor of Medicine (Dr. Kennedy).

Arch Intern Med. 1962;109(2):192-200. doi:10.1001/archinte.1962.03620140064010

It is now recognized that there is considerable variation in the clinical manifestations,1,2 the origin, and character of metastatic carcinoid tumors. A malabsorption syndrome3 and scleroderma4 may accompany the carcinoid syndrome. This syndrome may be produced by bronchial carcinoids with metastases,5-8 oat-cell carcinoma,9 argentaffinoma of the lung without hepatic metastases,10 and pancreatic carcinoma with demonstrated 5-hydroxytryptophan decarboxylase activity.11 The syndrome is apparent in only 20% of patients with carcinoid tumors and hepatic metastases12 and may rarely be associated with normal levels of 5-hydroxyindoleacetic acid (5-HIAA) excretion in the urine.13,14

The possible association of carcinoid syndrome and Cushing's syndrome has been suggested by the report of Harrison15 of a patient with bronchial carcinoma and clinical features of adrenal hyperplasia. In their patient 17-ketosteroid excretion was normal and 5-HIAA excretion in the urine was moderately increased as shown by paper chromatography.

First Page Preview View Large
First page PDF preview
First page PDF preview