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February 1962

Adrenergic Mechanisms

Author Affiliations

By J. R. Vane, B.Sc., Ph.D.; G. E. W. Wolstenholme, O.B.E., M.A., M.B., M.R.C.P.; and M. O'Connor, B.A. Price, $12.50. Pp. 632, with 163 illustrations. Little, Brown & Company, Inc., 34 Beacon St., Boston 6, 1960.

Arch Intern Med. 1962;109(2):247. doi:10.1001/archinte.1962.03620140119019

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Adrenergic mechanisms are of widespread importance in the regulation of function and reaction to stimulus of many body organs. Although our knowledge of these mechanisms is still very fragmentary, the area has been the subject of intense investigative interest and progress during the last few years. This report of a Ciba Symposium is a welcome means for the casual observer to become au courant with the most recent observations and theories in this field.

The symposium begins with a discussion of the biosynthesis, metabolic degradation, and storage of the catechol amines. Some excellent discussions concerning our present understanding of the mechanism of action of bretylium, guanethidine, and other adrenergic inhibitors and blocking agents follow. Of particular interest is a review of the recently elucidated mechanism of adrenalin action on carbohydrate metabolism involving the increased formation of cyclic adenylic acid and the activation of phosphorylase by Professors Sutherland and Lundholm. The

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