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Article
March 1962

Triglycerides, Lipoproteins, and Coronary Artery Disease

Author Affiliations

NEW HAVEN, CONN.

Department of Medicine, West Virginia University Medical Center, Morgantown, W. Va.

Arch Intern Med. 1962;109(3):345-359. doi:10.1001/archinte.1962.03620150095013
Abstract

The present state of knowledge of lipid metabolism and vascular disease has been achieved by advances in many disciplines. The contributions of the basic sciences cannot be clearly separated from those of clinical medicine and epidemiology because of the immense impact of each on the others. The present summary will include, therefore, references to relevant clinical observations as well as to more basic experiments in an attempt to find working hypotheses supported by data from various fields. Particular consideration will be given to the relation of serum triglyceride abnormalities to other serum lipid derangements which have been reported in this disorder.

Serum Lipid Derangements in Coronary Artery Disease  The various findings which have been reported are in part a reflection of available methods and include elevation of serum cholesterol concentration and of cholesterol: phospholipid ratio, a relative or absolute increase in low density or β-lipoproteins, an increased triglyceride concentration, and

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