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May 1962

Cushing's Syndrome Associated with Chromophobe Adenoma of Pituitary

Author Affiliations


From the Medical Service, Veterans Administration Hospital, Philadelphia.; Assistant Chief, Medical Service, Philadelphia Veterans Administration Hospital and Clinical Professor of Medicine, Woman's Medical College of Pennsylvania (Dr. Myerson): Formerly Resident in Medicine (Dr. Hingston).

Arch Intern Med. 1962;109(5):609-611. doi:10.1001/archinte.1962.03620170107018

Chromophobe adenomas of the pituitary are usually endocrinologically inactive and produce signs and symptoms only as a result of expansion. There are, however, some well-documented examples of this lesion associated with Cushing's syndrome.1-7 The importance of recognizing this association has been emphasized by recent reports of progressive enlargement of chromophobe adenomas following adrenalectomy for Cushing's syndrome.8-10 The evidence suggests the possibility that the pituitary tumor was present prior to surgery and that removal of the adrenals resulted in its expansion.

The following case represents a 40-month follow-up of a patient with Cushing's syndrome associated with a radiologically demonstrable pituitary tumor. The patient was successfully treated by surgical removal of the tumor and irradiation of the sella turcica. The tumor was identified histologically as a chromophobe adenoma.

Report of Case  A 39-year-old white man was admitted to the Veterans Administration Hospital, Philadelphia, on Oct. 12, 1957. During the 10

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