Chromophobe adenomas of the pituitary are usually endocrinologically inactive and produce signs and symptoms only as a result of expansion. There are, however, some well-documented examples of this lesion associated with Cushing's syndrome.1-7 The importance of recognizing this association has been emphasized by recent reports of progressive enlargement of chromophobe adenomas following adrenalectomy for Cushing's syndrome.8-10 The evidence suggests the possibility that the pituitary tumor was present prior to surgery and that removal of the adrenals resulted in its expansion.
The following case represents a 40-month follow-up of a patient with Cushing's syndrome associated with a radiologically demonstrable pituitary tumor. The patient was successfully treated by surgical removal of the tumor and irradiation of the sella turcica. The tumor was identified histologically as a chromophobe adenoma.
Report of Case
A 39-year-old white man was admitted to the Veterans Administration Hospital, Philadelphia, on Oct. 12, 1957. During the 10
MYERSON RM, HINGSTON WL. Cushing's Syndrome Associated with Chromophobe Adenoma of Pituitary. Arch Intern Med. 1962;109(5):609-611. doi:10.1001/archinte.1962.03620170107018