June 1962


Arch Intern Med. 1962;109(6):774. doi:10.1001/archinte.1962.03620180136030

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In the article, "Corticosteroid Metabolism in Liver Disease", by Drs. Harold Brown and Edwin Englert, Jr., published in the May 1961, issue of the Archives, editorial changes in the names of the drugs, dihydrocortisone for dihydrohydrocortisone and tetrahydrocortisone for tetrahydrohydrocortisone, caused Compound F to produce derivatives of Compound E instead of its own derivatives. The incorrect sentences should read as follows:

For example, hydrocortisone may be converted to cortisone, cortolone, dihydrohydrocortisone, and 11-β-hydroxy-androstenedione by fibroblasts.35

(Page 777, first column, first paragraph, beginning on line 22)

The first step in the liver is the reduction of hydrocortisone to dihydrohydrocortisone by a specific δ-hydrogenase in the soluble fraction of the liver cell with stereo specificity to the 5β isomer.43

(Page 777, second column, first paragraph, first sentence)

The next step is the reversible reduction of dihydrohydrocortisone to tetrahydrohydrocortisone by a relatively nonspecific 3α-hydroxysteroid dehydrogenase in the soluble fraction of the

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