Increased attention has been directed to mucormycosis over the past decade by both clinicians and pathologists. In large measure, this is attributed to the survival of patients having a variety of disorders that tend to lower host resistance or to enhance invasiveness of fungi belonging to 1 of 3 usually saprophytic genera of the family Mucoraceae (Mucor, Rhizopus, Absidia). Of 50 previously reported patients with mucormycosis, 25 were diabetics (most of whom had been severely acidotic) and 13 suffered from leukemia or lymphoma.1,2 Other predisposing disorders include myeloma, carcinoma, anemia, body burns, glomerulonephritis, acute tubular necrosis, hepatitis, cirrhosis of the liver, ionizing radiation, and the administration of antibiotics, steroids, or folic acid antagonists in large doses or over prolonged periods.
The present case report cites a young diabetic with recurrent severe acidosis in whom a large necrotic area of the skin was shown histologically to be due to such fungal
ROBERTS HJ. Cutaneous MucormycosisReport of a Case with Survival. Arch Intern Med. 1962;110(1):108–112. doi:10.1001/archinte.1962.03620190110017