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December 1962

Gram-Negative BacteremiaI. Etiology and Ecology

Author Affiliations


Formerly Research Fellow in Infectious Diseases, Research and Educational Hospital; Clinical Investigator, Veterans Administration West Side Hospital; Instructor in Medicine, University of Illinois College of Medicine (Dr. McCabe); Professor of Medicine, University of Illinois College of Medicine (Dr. Jackson).; From the Department of Medicine, Research and Educational Hospitals, University of Illinois College of Medicine.

Arch Intern Med. 1962;110(6):847-855. doi:10.1001/archinte.1962.03620240029006

The pattern of life-threatening bacterial infections has changed since the introduction of potent antimicrobial agents. Infections caused by pneumococci and β-hemolytic streptococci are less frequent causes of potentially fatal infections, and severe infections caused by staphylococci, other bacteria, and fungi are relatively more frequent.1-3 The importance and increasing incidence of infections caused by Gram-negative bacilli have been pointed out by several investigators,1,4-7 but infections caused by these microorganisms have received less attention than those due to staphylococci. This report reviews the experience with Gram-negative bacteremia during an 8-year period at the University of Illinois Research and Educational Hospitals. The etiology and some aspects of the ecology of these infections have been determined and are reported in this paper. Clinical manifestations, the effect of corticosteroid administration, and antibiotic prophylaxis and therapy of Gram-negative bacteremia are given in another report.

Clinical Material  All blood culture isolates of a species of

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