April 1963

Tissue Lipid Patterns in a Case of Xanthoma Disseminatum

Author Affiliations


Assistant Resident in Medicine (Dr. Blount); Assistant Resident in Dermatology (Dr. Cohen).; Departments of Medicine and Dermatology, Medical College of Virginia.

Arch Intern Med. 1963;111(4):511-517. doi:10.1001/archinte.1963.03620280111017

Xanthoma disseminatum is a rare disease characterized by xanthomatous lesions composed of proliferating mature histiocytes, foam cells with high cholesterol content, eosinophils, Touton cells, and fibrosis. Plaquelike skin lesions are usually seen over flexor surfaces of joint areas with multiple organ systems involved. Serum cholesterol and other serum lipid fractions are typically normal. A case of xanthoma disseminatum in a Negro female with widespread xanthomatous involvement and the finding of associated diabetes mellitus with secondary hyperlipemia is presented as the first reported case in a Negro and as an illustration of the lipid analysis of xanthomatous lesions, including fatty acid distribution by the gas chromatographic technique.

Report of a Case 

History.—  First admission: A 33-year-old Negro housewife was admitted to the Medical College of Virginia Hospitals on July 12, 1960, with the history that 10 to 12 years prior to admission she had noted raised nontender pea-sized nodules of the

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