May 1963

Megaloblastic Anemia Coexistent with Benign Pyloric Stenosis

Author Affiliations


Instructor in Medicine (Dr. Levere); Associate Professor of Medicine (Dr. Lichtman); State University of New York, Downstate Medical Center.; From Department of Medicine, State University of New York Downstate Medical Center, and the Kings County Hospital Center.

Arch Intern Med. 1963;111(5):631-633. doi:10.1001/archinte.1963.03620290097012

A variety of gastrointestinal disorders have been implicated in the causation of megaloblastic anemia which responded to the parenteral administration of cyanocobalamin (vitamin B12).1,2 However, there are no reports of the coexistence of this type of anemia with pyloric obstruction produced by benign fibrosis. The case to be described represents an example of this occurrence.

Report of a Case  A 57-year-old white housewife, of Italian descent, was hospitalized for evaluation of anemia. She was in good health until approximately one year prior to admission, when she began to experience episodes of nausea and vomiting occurring shortly after meals. Soon thereafter insidious weakness developed. These symptoms progressed over the year preceding admission, and during the month prior to hospitalization she vomited all solid foods and had been able to retain only small quantities of orally ingested liquids. She noted no blood in her vomitus. Two weeks before hospitalization she

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