Thyroid carcinoma has been observed in a significant number of children and adolescents who received x-ray therapy to the thymus in infancy and early childhood.1-7 A less significant number of adults developing thyroid carcinomas after irradiation have been reported.7-11 In a survey of 70 radiologists and 31 thyroid specialists in 1949, Quimby and Werner12 reported that none had ever seen thyroid carcinoma develop in a normal thyroid gland when that region had been in the field of x-ray for another condition.
The purpose of this paper is to report a case of thyroid carcinoma in an adult male who received external x-ray to the neck at eight years of age for "Hodgkin's disease." His thyroid gland at the time of x-ray therapy was clinically normal and remained so for 13 years before enlargement was noted. Enlargement initially occurred on the side of his neck exposed to the
MORRIS JH, HARDIN CA. Thyroid Cancer in Adult Following External Irradiation. Arch Intern Med. 1964;113(1):97-100. doi:10.1001/archinte.1964.00280070099016