March 1964

Amino Acid Excretion in Familial Mediterranean Fever

Author Affiliations


Clinical Associate (Dr. Rubenstein) and Senior Investigator (Dr. Wolff).

Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Arch Intern Med. 1964;113(3):409-411. doi:10.1001/archinte.1964.00280090095015

Introduction  Familial Mediterranean fever (FMF) is a disease characterized by recurrent episodes of fever, peritonitis, or pleuritis,1 which is probably inherited as an autosomal recessive disorder.2 Most of the patients reported with FMF have been of Armenian 3 or Sephardic Jewish ancestry.1 Although the etiology of FMF is unknown, it has been suggested it may be an "inborn error of metabolism" 4 or probably a manifestation of a hypersensitive state.5It was recently reported that some FMF patients excreted increased amounts of urinary histidine as measured by two-dimensional paper chromatography.4,6,7 On the basis of these reports, aminoaciduria has been suggested as a differential diagnostic criterion for FMF.8 We have studied the amino acid excretion with ion-exchange chromatography in five FMF patients both while they were afebrile and pain free and also during spontaneous episodes of fever and peritonitis. The results of these studies demonstrate

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