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July 1964

Fundamentals of Acid-Base Regulation.

Arch Intern Med. 1964;114(1):176. doi:10.1001/archinte.1964.03860070222052

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This 78-page paperback on hydrogen ion regulation is well bound and tolerates usage well. There are 26 succinct chapters, some only two or three pages long, written in splendid scientific English, rendering comprehension of the movements of hydrogen ion in the body exceedingly clear. There are many such books available on the market today, but this reviewer has seen none as well written and free of verbosity as this one. Beginning with the problem of nomenclature, proceeding through respiratory, renal, and buffer regulation of hydrogen ion, the author proceeds to the application of clinical circumstances, though not in terms of specific clinical cases. There are some minor objectionable points. Sodium is given credit for regulating osmotic pressure; the chemical activity of water accounts for osmotic pressure. Hydrogen ion regulation seems a better term than acid-base regulation. The so-called paradox of excretion of an acid urine in potassium-depleted patients continues to

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