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Article
August 1964

Hemoglobin D in an Oklahoma Family

Author Affiliations

OKLAHOMA CITY; McALESTER, OKLA; OKLAHOMA CITY

From the University of Oklahoma Medical Center, Oklahoma City, and the McAlester Clinic, Mc-Alester, Okla.; Assistant Professor, Department of Medicine, University of Oklahoma School of Medicine (Dr. Stout); Member, Department of Medicine, Mc-Alester Clinic (Dr. Holland); Professor, Department of Medicine, University of Oklahoma School of Medicine (Dr. Bird).

Arch Intern Med. 1964;114(2):296-300. doi:10.1001/archinte.1964.03860080146016
Abstract

Introduction  In 1952 Itano 1 reported the finding of a new hemoglobin which migrated electrophoretically in the same position as hemoglobin S. This new hemoglobin was found to be much more soluble than hemoglobin S, and the erythrocytes which contained it could not be induced to sickle. It was assigned the letter D. Since then hemoglobin D has been found in Sikhs in India,2 in Algerian Moslems,3 in a Persian girl,4 in a Turkish family,5 and in others.6-8 In a survey of 1,000 Negroes in St. Louis, Chernoff found four instances of hemoglobin D trait.9 In Baltimore, four cases of hemoglobin D trait were found in a survey of 400 Negroes with hemoglobin S trait.10 Several white families have been described in which hemoglobins S and D were present simultaneously.11,12 Homozygosity for Hgb D has been seen infrequently. The reason for this is not clear, since the

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