September 1964

Short-Term Drug Effects on Thyroid Function Tests

Author Affiliations


From the Departments of Medicine, Western Reserve University School of Medicine and University Hospitals.

Arch Intern Med. 1964;114(3):413-416. doi:10.1001/archinte.1964.03860090147017

The effects of certain medications on tests of thyroid function are well known. How soon these effects manifest themselves is not so well known and frequently becomes a matter of some importance to physicians interpreting the results of such tests.

To instruct third-year medical students in the interpretation of thyroid function tests, an exercise was designed in which each willing member of the class received one of six medications daily for one week. At the end of the medication period, the following tests were performed on each student: 24-hour thyroidal uptake of a tracer dose of I131, PBI, and the resinsponge uptake of liothyronine I 131 (radioactive triiodothyronine). The students and their instructor attempted to deduce the medications taken from the data collected. The results obtained are the subject of this report.

Materials and Methods  While the 80 medical students of the class of 1965 were being presented the

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