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December 1964

Experimental Histoplasmic Endocarditis

Author Affiliations


From the Departments of Internal Medicine and Pathology, University of Cincinnati, College of Medicine and the Clinical Laboratories, Jewish Hospital.

Arch Intern Med. 1964;114(6):784-791. doi:10.1001/archinte.1964.03860120096010

The first case of histoplasmosis was reported in 1906 by Darling who described a generalized fatal infection in a patient in Panama.1 Thirty-seven years later, a case of endocarditis due to Histoplasma capsulatum was reported for the first time from Rochester, Minn.2 In a review of fungal endocarditis in 1959, Merchant et al summarized 11 cases of histoplasma endocarditis reported in the literature up to 1958.3 Since then, four additional cases have been reported.4-7 Diagnosis of histoplasmic endocarditis was not made during life in any of these 15 patients, except in one who had embolic occlusion of the left femoral artery. Embolectomy was carried out in this patient, and in microscopic sections of the clot, numerous organisms of H capsulatum could be observed. She was treated with amphotericin B and was the only reported patient who apparently survived the infection.4 Only two other patients had any treatment with amphotericin B.

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