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Dr. McDonald has contributed an excellent work in this study of hemochromatosis and hemosiderosis. He begins his book by discussing the problems in the present-day concepts of hemochromatosis, pointing them out broadly and where necessary in detail; and he furnishes a superb critical review of the literature relating to iron metabolism and hemochromatosis.
Through many years of diligent study, MacDonald has arrived at a dual concept of hemochromatosis. He considers dietary hemochromatosis to be the result of ingesting excessive dietary iron in a patient who also has a separate condition such as alcoholism, malnutrition, viral hepatitis, vascular congestion, or biliary obstruction which results in cirrhosis of the liver. He defines parcntcral hemochromatosis as the result of association of excessive parenteral
Silverstein MN. Hemochromatosis and Hemosiderosis.. Arch Intern Med. 1965;115(2):256. doi:10.1001/archinte.1965.03860140136044