WHAT are the consequences of a pulmonary parenchymal lesion due to sarcoid? The question is not answered definitively from large series of patients, for example, that of Hoyle and Smellie,1 followed clinically and radiologically for extended periods, since Marshall and co-workers 2 found functional abnormalities in five of six of these patients whose x-ray had cleared. For the same reason the careful physiological studies of Svanborg3 on patients with radiologic "fibrosis" are not a full answer. It seemed to us worthwhile, therefore, to study patients in whom duration of disease rather than radiologic appearance was the criterion for investigation and to report clinical, radiologic, and functional findings in ten patients five or more years after the onset of parenchymal lesions due to sarcoid.
Materials and Methods
Between 1956 and 1963, 34 patients in whom a diagnosis of sarcoid was made on clinical grounds and substantiated by biopsy
LEWIS BM, KURTZMAN RS, MARTIN ND, BOUSHY SF. Effects of Sarcoid On the Lungs. Arch Intern Med. 1965;115(3):330-335. doi:10.1001/archinte.1965.03860150074014