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June 1965

Chronic Erythroleukemia With Chromosome MosaicismReport of a Case in a 5-Year-Old Boy

Author Affiliations


From the Department of Pathology, Division of Hematology, Research Institute, the Hospital for Sick Children, and the University of Toronto. Assistant Pathologist (Hematology), and Clinical Assistant, the Hospital for Sick Children, and Clinical Teacher, Department of Pediatrics, University of Toronto (Dr. McClure); Senior Research Fellow, the Research Institute, the Hospital for Sick Children (Dr. Thaler); and Research Pathologist, the Hospital for Sick Children, and Research Associate, Department of Pathology, University of Toronto (Dr. Conen).

Arch Intern Med. 1965;115(6):697-703. doi:10.1001/archinte.1960.03860180069012

LIKE OTHER myeloproliferative disorders, erythroleukemia (DiGuglielmo's disease) may occur in acute or chronic form. The acute disease is more common, and terminates fatally within months. The chronic form may persist for years, and usually produces few symptoms, other than those associated with anemia. Most chronic cases feature involvement of the myeloid series as well as the characteristically abnormal erythroblastic proliferation in the marrow. Myeloblastic involvement becomes more likely the longer the disease persists, hence the name "erythroleukemia." Because of variation from case to case, extreme rarity of the condition, and unknown etiology, classification has been difficult and confusing. Most authors agree that the essential feature of the disease, as described by DiGuglielmo in 1917,1 is a generalized malignant proliferation of the erythropoietic cells of the bone marrow. Though several reports of chronic erythroleukemia in adults are now available, we are presenting the first such instance in a young child,

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