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This book is a comprehensive and well-documented review of current knowledge about chemical substances capable of producing pain and/or itch. The authors are obviously competent in this sphere of interest, having made many important contributions themselves which are reviewed in the appropriate place in the text, with the slightly greater detail, yet reasonable modesty, that one may expect in such a work.
The authors, their own experimental work, and this book all owe and acknowledge a great debt to Sir Thomas Lewis who pioneered an important and fertile new field. His cleverness and thoroughness of experimental design, using remarkably simple technical means, have apparently inspired well the subsequent generation of his scientific progeny. The directness and simplicity of methods and observations is related, of course, to the use of the skin as the major object of study, providing as it does such a happy opportunity for direct in vivo investigation,
Caplan RM. Substances Producing Pain and Itch.. Arch Intern Med. 1965;115(6):753. doi:10.1001/archinte.1960.03860180125037