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Article
July 1965

Cerebral Salt-Wasting Associated With the Guillain-Barré Syndrome

Author Affiliations

USN; USN; TAIPEI, TAIWAN, REPUBLIC OF CHINA

From the Clinical Investigation Department, US Naval Medical Research Unit No. 2 (NAMRU-2). Clinical investigator (Dr. Cooper) and virologist (Drs. Green and Wang). Present addresses: Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Mass (Dr. Cooper); University of California Medical Center, Los Angeles (Dr. Green); Department of Preventive Medicine, University of Washington School of Medicine, Seattle (Dr. Wang).

Arch Intern Med. 1965;116(1):113-119. doi:10.1001/archinte.1965.03870010115014
Abstract

INAPPROPRIATE secretion of antidiuretic hormone has been implicated as the cause of the hyponatremia and renal salt-wasting associated with certain cases of intracranial and intrathoracic disease. Cases of traumatic, infectious, and neoplastic intracranial disease, and of neoplastic thoracic disease have been associated with the salt-wasting syndrome.1-6 The following is a report of the simultaneous occurrence in a patient of an illness clinically indistinguishable from the Guillain-Barré syndrome and of an electrolyte disturbance marked by transient loss of renal sodium-conserving ability, plasma hypo-osmolality, and plasma hyponatremia. Immunologic features of this patient's illness suggested to us that the etiology of the polyradiculoneuropathy was hypersensitivity to viral antigens.

Report of a Case  A 32-year-old Taiwanese man, a virology technician at the US Naval Medical Research Unit No. 2 (NAMRU-2), was admitted to Taiwan University Hospital on Sept 16, 1961, with the chief complaint of walking disturbance and pain in the left

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