GAMMA globulins obtained from normal persons and from patients with multiple myeloma have been well characterized. Their immunochemical differences are clearly recognized. Immunoelectrophoretic studies led to the division of these proteins into three basic groups: 6.6S, 7S globulin, β2A and β2M-globulin.1-5 Immune globulins are formed almost entirely in normal plasma cells and their precursors, or result from the metabolism of malignant plasma cells. High levels of individual immune globulins, or structurally abnormal globulins, are usually associated with malignant but immunologically competent cells.
According to Waldenström, however, hypergammaglobulinemia may occur in benign conditions, or as a familial disease. Pathological abnormalities in lymph nodes may be absent.
Changes in immune globulins may be associated with various pathological phenomena; the best known are the altered immune response and hemorrhagic disorders.6 The abnormalities usually result from an anomaly in β2M or γ7S-globulin; they are less common as a result of β2M
WYSOCKI K, MACKIEWICZ S. Familial Anomalous B2A—GlobulinAccompanied by Disorders of Blood Coagulation and Pathologic Immune Phenomena. Arch Intern Med. 1965;116(3):351–356. doi:10.1001/archinte.1965.03870030031007