September 1965

Parkinsonism in Postoperative Hypoparathyroidism

Author Affiliations


From the Department of Medicine, Henry Ford Hospital. Physician-in-Charge, Fifth Medical Division.

Arch Intern Med. 1965;116(3):424-427. doi:10.1001/archinte.1965.03870030104017

CALCIFICATION in the region of the basal ganglia occurs in a number of disease states and may be associated with the clinical features of parkinsonism. Such calcification is seen frequently in idiopathic- and pseudohypoparathyroidism.1 In contrast, it is reported to be of rare occurrence in postoperative hypoparathyroidism.2,3

The purpose of this report is to present three patients who developed parkinsonism following thyroidectomy, two of whom had calcification in the region of the basal ganglia. The relation between hypoparathyroidism, basal ganglia calcification, and parkinsonism will be discussed.

Report of Cases 

Case 1.  —A 68-year-old woman (HFH 05-10-18) had a subtotal thyroidectomy for a nontoxic goiter in 1940. Following this operation, she experienced hoarseness and muscle cramping which subsided after treatment with oral calcium supplements. The patient was then well until 1960, at age 65, when she experienced increasing fatigue, muscle stiffness, and leg cramps. She also noticed tremor of

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