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September 1965

Giant-Cell Myocarditis With Multiple Organ Involvement

Author Affiliations


From the departments of pathology and internal medicine, Methodist Hospital Graduate Medical Center. Clinical Pathologist (Dr. Palmer); Staff Physician, Internal Medicine (Dr. Michael).

Arch Intern Med. 1965;116(3):444-447. doi:10.1001/archinte.1965.03870030124022

SINCE the first description of giant-cell myocarditis in 1905 by Saltykow, 21 additional cases have been reported in the English literature through 1963.1-9 It is the purpose of this paper to record a case having multiple organ involvement and to emphasize the giant-cell arteritis seen in the myocardium.

Report of a Case  The present illness of this 36-year-old white female began on Sept 1, 1961, with nausea, vomiting, and diarrhea. She improved with supportive and symptomatic treatment until Sept 3, when she experienced a sudden onset of dyspnea and tachycardia with an apical rate of more than 200 beats per minute. Orthopnea and cyanosis then ensued and she entered Indianapolis Methodist Hospital in a critical state. Physical examination revealed cyanosis, difficulty in breathing, gallop rhythm, and shock. She died in refractory congestive heart failure 16 hours after entering the hospital.A thyroidectomy was performed at age 15 years because

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