September 1965

Dynamic Clinical Studies With Radioisotopes.

Author Affiliations

Edited by Ralph M. Kniseley, MD; W. Newlon Tauxe, MD; and Elizabeth B. Anderson, MS. Price, $4.50. Pp 634. USAEC Division of Technical Information Extension, Oak Ridge, Tenn; available from Office of Technical Services, US Department of Commerce, Washington, DC 20230, 1964.

Arch Intern Med. 1965;116(3):481. doi:10.1001/archinte.1965.03870030161059

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Not long ago dynamic clinical studies with radioisotopes consisted primarily of the measurements of appearance time, accumulation of the radioisotope, and in a few isolated examples, dilution or clearance. In the last few years the techniques of improved data recording and computer processing have combined with advances in the tagging of new radioactive compounds to give the investigator the much needed confidence to apply the more complex models of compartment analysis to his studies.

This symposium owes a great deal of its success to Dr. Kniseley who selected 23 investigators representing varied approaches to the analysis of kinetic problems. In many cases more similarity has been found between models of different physiological systems than between two investigators reporting on the analysis of the same system. As a result, while many biochemical or physiological systems are not included, there are very few approaches or methods which have not been represented.


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