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October 1965

Systemic Lupus and Polyneuropathy

Author Affiliations


From the Division of Neurology (Department of Medicine), University Hospitals of Cleveland, and Highland View Hospital. Dr. Lewis, formerly Second-Year Assistant Resident in Medicine, University Hospitals of Cleveland, is currently Clinical Fellow in Arthritis, University of Texas Southwestern Medical School, Dallas.

Arch Intern Med. 1965;116(4):518-522. doi:10.1001/archinte.1965.03870040032008

COLLAGEN DISEASES affect the peripheral nervous system in two ways. One is a mononeuritis or mononeuritis multiplex that has been reported in periarteritis,1-4 rheumatoid arthritis,5 rheumatoid arthritis with arteritis,5-8 and lupus erythematosus.9-12 The other form of peripheral-nerve involvement, a symmetrical polyneuritis, has been reported to occur in periarteritis,1,13,14 scleroderma,15,16 rheumatoid arthritis,2,5,6, 17,18 rheumatoid arthritis with arteritis,5,8,17 and lupus erythematosus.2,9,19,20 All told, there are about 200 well-documented cases of peripheral neuropathies in collagen disease, but only a few of these cases involved systemic lupus. However, a recent tabulation of 520 cases of lupus by Dubois and Tuffanelli,21 reporting an 11.7% incidence of some form of peripheral neuropathy with lupus, suggests that this manifestation may be more common than was heretofore thought. This communication presents a case of systemic lupus erythematosus with severe symmetrical polyneuritis and reviews the related literature.

Report of a Case  A 50-year-old Negro woman was admitted to

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